Inflammation
Study links GDF3 signaling in aging macrophages to heightened inflammation and worse outcomes in infection models
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University of Minnesota researchers report that older mice’s macrophages can become locked in an inflammatory state through an autocrine signaling loop involving the protein GDF3 and the transcription factors SMAD2/3. In experiments, genetic deletion of Gdf3 or drugs that interfered with the pathway reduced inflammatory responses and improved survival in older endotoxemia models, while human cohort data linked higher GDF3 levels with markers of inflammation.
New research shows that visceral fat around the waist increases heart failure risk more than BMI, even among those with normal weight. Inflammation mediates much of this link. The findings were presented at the American Heart Association's EPI|Lifestyle Scientific Sessions 2026 in Boston.
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Building on genomic research linking Alzheimer's origins to inflammation in peripheral tissues like the gut, lungs, or skin, practical lifestyle measures can help curb chronic inflammation. These include vaccination, oral hygiene, diet, exercise, weight control, and stress management, offering benefits for overall health amid evolving science.