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Study links uneven PARP inhibitor exposure in ovarian tumors to lysosomal drug “reservoirs”
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Researchers say they have identified a cellular mechanism that may help explain why PARP inhibitors can affect tumor cells unevenly: in lab-grown slices of human ovarian tumors, some of these drugs accumulated inside lysosomes, forming slow-release stores that created patchy drug distribution across tissue and even between neighboring cells. The findings were reported in a 2026 paper in Nature Communications.
Researchers at LMU Munich, Bonn-Rhein-Sieg University of Applied Sciences, TU Darmstadt and Nanion Technologies report that the lysosomal ion channel TMEM175 helps prevent excessive acidification inside lysosomes, a malfunction that the team says could contribute to toxic buildup associated with Parkinson’s disease. The findings were reported in the Proceedings of the National Academy of Sciences.
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Researchers analyzing immune cells from people with long COVID have identified a distinct molecular state in CD14+ monocytes—labeled “LC-Mo”—that was more prevalent among patients whose initial COVID-19 illness was mild to moderate and that tracked with reported fatigue and respiratory symptoms, along with higher levels of inflammatory signaling molecules in blood plasma.
A real-world study of nearly 8,000 patients by Cleveland Clinic researchers shows that stopping injectable semaglutide or tirzepatide often does not lead to major weight regain. Many participants maintained or continued losing weight by restarting treatment, switching medications, or using lifestyle support. This differs from clinical trials where rapid regain was observed.
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A new study found that the shingles vaccine reduced major cardiac events by 46% and deaths by 66% in people with atherosclerotic heart disease. The research, presented at the American College of Cardiology's Annual Scientific Session, examined over 246,000 US adults aged 50 and older.
Experiments suggest Neanderthals could have applied birch tar, found at their sites, as an antiseptic for wounds due to its antibiotic properties. Researchers replicated ancient production methods and tested the tar against bacteria causing skin infections. The findings build on evidence of Neanderthals using medicinal plants.
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Researchers tested a redesigned CD40 agonist antibody, 2141-V11, by injecting it directly into tumors of 12 patients with metastatic cancers. Six patients saw tumor shrinkage, with two achieving complete remission, including effects on untreated tumors elsewhere in the body. The trial reported only mild side effects, unlike prior CD40 therapies.
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