Mitochondria
Scientists uncover cancer cells' mitochondrial energy surge under pressure
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Researchers have discovered that cancer cells respond to physical squeezing by rapidly deploying mitochondria to the nucleus, delivering a burst of ATP to repair DNA damage and ensure survival. This mechanism, observed in lab experiments and patient biopsies, could inspire new strategies to halt cancer spread. The finding redefines mitochondria's role as dynamic responders rather than static energy sources.
Cellular switch discovery offers hope for Parkinson's treatment
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Scientists have identified a key cellular regulator called PP2A-B55alpha that balances mitochondrial health, potentially leading to new therapies for Parkinson's disease. In preclinical models, reducing its activity improved motor symptoms and mitochondrial function. The findings, published in Science Advances, could extend to other mitochondrial disorders and cancer.