Mitochondria
EPFL study links mitochondrial “pearling” to the even spacing of mtDNA nucleoids
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Scientists at EPFL report that a transient shape change in mitochondria—known as “pearling,” in which the organelle briefly forms bead-like constrictions—can redistribute clusters of mitochondrial DNA (mtDNA) into more evenly spaced nucleoids. The work, published April 2, 2026 in Science, suggests the process is triggered by calcium influx into mitochondria and may help explain how cells maintain robust mtDNA organization, a feature implicated in a range of mitochondrial-related disorders.
Researchers in Japan have discovered that boosting a protein called COX7RP in mice improves mitochondrial function, leading to longer lives and better health. The engineered mice lived 6.6% longer on average, with enhanced metabolism and reduced signs of aging. This finding points to potential ways to promote healthier aging in humans.
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Scientists at the University of California, Riverside have identified a previously unknown form of mitochondrial DNA damage known as glutathionylated DNA adducts, which build up at dramatically higher levels in mitochondrial DNA than in nuclear DNA. The lesions disrupt energy production and activate stress-response pathways, and researchers say the work could help explain how damaged mitochondrial DNA contributes to inflammation and diseases including diabetes, cancer and neurodegeneration.