Medical Science
Scientists identify cell-death enzyme that helps cancer cells survive treatment
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Researchers at the University of California San Diego report that certain cancer cells survive targeted therapies by using low-level activation of a cell-death–linked enzyme, enabling them to endure treatment and later regrow tumors. Because this resistance mechanism does not depend on new genetic mutations, it appears early in treatment and may offer a new target to help prevent tumor relapse.
Researchers have identified a previously unknown mechanism called karyoptosis that appears to drive the death of brain cells in Alzheimer's disease and frontotemporal dementia. The discovery, based on analysis of human brain tissue, points to a potential new target for treatments aimed at slowing neuron loss.
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Researchers at Baylor College of Medicine have found that the brain continues advanced language processing even during general anesthesia. Patients under unconsciousness distinguished parts of speech and anticipated upcoming words in stories. The results, published in Nature, challenge prior views on consciousness and cognition.