Medical Science
Scientists identify cell-death enzyme that helps cancer cells survive treatment
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Researchers at the University of California San Diego report that certain cancer cells survive targeted therapies by using low-level activation of a cell-death–linked enzyme, enabling them to endure treatment and later regrow tumors. Because this resistance mechanism does not depend on new genetic mutations, it appears early in treatment and may offer a new target to help prevent tumor relapse.
New studies reveal that preserving lymph nodes during cancer surgery could improve patient responses to immunotherapy by supporting key immune cells. Led by the Peter Doherty Institute, the research emphasizes lymph nodes' crucial function in training T cells to fight tumors. The findings, published in Nature Immunology, suggest rethinking surgical practices to boost treatment effectiveness.