Large genetic study uncovers new Alzheimer’s drug targets

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A major analysis of genetic data has linked 127 gene locations to Alzheimer’s disease, including 48 previously unidentified ones. Researchers also flagged several genes as promising drug targets and highlighted changes in immune and nerve cells.

The study examined genome information from nearly 110,000 people diagnosed with Alzheimer’s and 74,000 others who had a parent with the condition. It compared these against data from 2.6 million people without the disease. This effort identified 127 associated gene locations, 48 of which are new findings.

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Scientists call for multi-pronged strategies against Alzheimer's

A team of researchers led by Professor Yan-Jiang Wang has published a review arguing that Alzheimer's disease requires integrated treatments targeting multiple factors, not single causes. New drugs like lecanemab and donanemab offer modest benefits by slowing decline, but fall short of reversal. The paper, in Science China Life Sciences, emphasizes genetics, aging, and systemic health alongside amyloid-beta and tau proteins.

USC researchers identify compounds targeting Alzheimer’s brain inflammation

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Scientists at the University of Southern California have found experimental compounds that may reduce harmful brain inflammation associated with Alzheimer’s disease. The work focuses on the enzyme cPLA2 and people who carry the high-risk APOE4 gene.

Mechanic with Alzheimer's mutation avoids disease through heat exposure

Doug Whitney, a US mechanic carrying a genetic mutation that typically triggers early-onset Alzheimer’s disease, has reached his late 70s without symptoms. Researchers link his protection to decades of intense heat exposure in ship engine rooms. The case bolsters evidence that heat therapy may safeguard the brain against the condition.

Nanoparticles reduced amyloid-β and improved cognition in an Alzheimer’s mouse model, researchers report

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Researchers from the Institute for Bioengineering of Catalonia and collaborating institutions report that engineered “supramolecular” nanoparticles restored aspects of blood-brain barrier function in Alzheimer’s-model mice, rapidly lowering brain amyloid-β and producing improvements on behavioral and memory tests.

May 20, 2026 20:53

Study finds alzheimer's risk factors hit women harder

May 20, 2026 09:20

Indiana university team targets idol enzyme to treat alzheimer's

May 04, 2026 12:12

Cochrane review questions benefits of anti-amyloid Alzheimer’s drugs

April 30, 2026 12:13

Scientists restore memory in Alzheimer's mice by blocking PTP1B

March 12, 2026 21:43

New blood test spots Alzheimer's via protein shape changes

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