遺伝子データの大規模な分析により、アルツハイマー病に関連する127箇所の遺伝子領域が特定され、そのうち48箇所はこれまで未確認のものだった。研究チームは、有望な治療標的となる複数の遺伝子を指摘し、免疫細胞や神経細胞における変化を強調した。
本研究では、アルツハイマー病と診断された約11万人と、親が同疾患を患った7万4千人のゲノム情報を調査した。これらを、疾患のない260万人のデータと比較した。その結果、アルツハイマー病に関連する127箇所の遺伝子領域が特定され、そのうち48箇所が新たな発見となった。
A team of researchers led by Professor Yan-Jiang Wang has published a review arguing that Alzheimer's disease requires integrated treatments targeting multiple factors, not single causes. New drugs like lecanemab and donanemab offer modest benefits by slowing decline, but fall short of reversal. The paper, in Science China Life Sciences, emphasizes genetics, aging, and systemic health alongside amyloid-beta and tau proteins.
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Scientists at the University of Southern California have found experimental compounds that may reduce harmful brain inflammation associated with Alzheimer’s disease. The work focuses on the enzyme cPLA2 and people who carry the high-risk APOE4 gene.
Doug Whitney, a US mechanic carrying a genetic mutation that typically triggers early-onset Alzheimer’s disease, has reached his late 70s without symptoms. Researchers link his protection to decades of intense heat exposure in ship engine rooms. The case bolsters evidence that heat therapy may safeguard the brain against the condition.
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Researchers from the Institute for Bioengineering of Catalonia and collaborating institutions report that engineered “supramolecular” nanoparticles restored aspects of blood-brain barrier function in Alzheimer’s-model mice, rapidly lowering brain amyloid-β and producing improvements on behavioral and memory tests.