Genetics
Study pinpoints why BET inhibitors have underperformed: BRD2 and BRD4 do different jobs in gene activation
Ti AI ṣe iroyin Àwòrán tí AI ṣe Ti ṣayẹwo fun ododo
Researchers at the Max Planck Institute of Immunobiology and Epigenetics (MPI-IE) in Freiburg report that a key assumption behind widely used BET-inhibitor drug strategies may be wrong: the BET proteins BRD2 and BRD4 are not interchangeable. The team says BRD2 helps prepare genes for activation while BRD4 acts later to enable productive transcription—differences that could contribute to the modest and unpredictable results seen with drugs that inhibit BET proteins broadly.
A genetic analysis of more than a thousand ancient British genomes shows the Roman conquest left only a small mark on the island's ancestry despite major cultural shifts.
Ti AI ṣe iroyin Ti ṣayẹwo fun ododo
Researchers comparing appendage regrowth in salamanders, fish and mice report that two related genes, SP6 and SP8, are activated in regenerating skin tissue across species and are required for normal bone regrowth in animal models—findings they say could inform future regenerative-medicine strategies.
Scientists have found genetic evidence that modern humans reached New Guinea and Australia around 60,000 years ago, backing the long chronology over more recent estimates. The international team, led by researchers at the University of Huddersfield and the University of Southampton, analyzed nearly 2,500 mitochondrial DNA genomes from Aboriginal Australians, New Guineans, and Southeast Asian populations. Their work suggests early migrants used at least two routes through Southeast Asia.
Ti AI ṣe iroyin Ti ṣayẹwo fun ododo
Researchers at Kyoto University and RIKEN report that human cells can detect “non-optimal” synonymous codons—alternative three-letter genetic instructions that encode the same amino acid but are translated less efficiently—and selectively suppress the corresponding mRNAs. In experiments described in Science, the team identifies the RNA-binding protein DHX29 as a central component of this codon-dependent control of gene expression.
Researchers have found that polygenic risk scores, which summarize a person's likelihood of developing diseases like diabetes and cancer, can be reverse-engineered to uncover underlying genetic data. This vulnerability raises privacy concerns, potentially allowing identification through public databases or reconstruction by insurers. The discovery highlights risks in sharing such scores, even anonymously.
Ti AI ṣe iroyin
Scientists at EPFL have developed a technique called optovolution, using light to evolve proteins that switch states, sense environments, and perform computations. By engineering yeast cells to survive only if proteins behave dynamically, the method selects optimal variants rapidly. The approach, published in Cell, advances synthetic biology and optogenetics.
Twin study shows genetics shape success more than upbringing
May 07, 2026 05:18Scientists discover protist with unusual genetic code
May 06, 2026 01:14Mechanic with Alzheimer's mutation avoids disease through heat exposure
May 05, 2026 22:53Scientists enhance strawberry flavor and nutrition via gene tweak
May 04, 2026 22:52Scientists map Leonardo da Vinci family tree for DNA project
April 08, 2026 01:11Researchers identify SLC35F2 as a transporter that brings the micronutrients queuine and queuosine into human cells
March 26, 2026 20:54Snow flies generate their own heat to survive freezing cold
March 25, 2026 18:32Study shows cloned mice accumulate harmful mutations
March 25, 2026 10:29Oldest confirmed dog remains date to 15,800 years ago in Turkey
March 17, 2026 00:20Ancient DNA reveals ethnic diversity among Goths