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Microscopic illustration of migrating neurons in the developing brain showing DNA damage and repair.
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Developing neurons sustain and rapidly repair DNA double-strand breaks during migration, study finds

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A study in Nature reports that newborn neurons can incur double-strand DNA breaks while squeezing through tight spaces in the developing brain, and that healthy cells typically repair most of this damage within about a day.

A US company plans to offer an unapproved gene therapy designed to boost levels of an anti-ageing protein called klotho. The treatment will be provided at clinics in Honduras, the Bahamas and Panama. It aims to bypass US regulatory requirements.

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Researchers have identified a rare genetic mutation that may help people from long-lived families stay healthier longer by reducing harmful inflammation. The findings were presented at the European Society of Human Genetics conference in Gothenburg.

A major analysis of data from more than a million women has identified hundreds of genes tied to endometriosis. The research also connects the condition to inflammation, cholesterol regulation and gut bacteria changes.

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Researchers say genetic variants in the PAM gene may help explain why some people with Type 2 diabetes get less blood-sugar benefit from GLP-1 receptor agonist drugs such as Ozempic, a phenomenon they describe as “GLP-1 resistance.”

A federally funded mouse study has revealed that some inherited traits follow non-Mendelian patterns through epigenetic changes. The research identified hundreds of unexpected DNA methylation events across generations. It also documented the first known natural paramutation in a mammal.

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New genetic analysis reveals close interactions between Europe's early farmers and hunter-gatherers, with women driving the spread of farming in northwestern regions. Later migrations reshaped populations as far as Britain.

 

 

 

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