DNA scar catalog opens paths to overcome cancer drug resistances

3. oktober 2025 Rapportert av AI

Researchers at Spain's National Cancer Research Centre (CNIO) have developed a comprehensive catalog of mutational 'scars' in DNA caused by cancer. This breakthrough, published in Nature, could help bypass resistances to treatments like PARP inhibitors. The study analyzes thousands of tumor samples to identify key genetic patterns.

Illumina AI Tool for Rare Diseases

Illumina introduced an AI tool aiding in the diagnosis of rare diseases. This innovation enhances genetic analysis for complex conditions. It was highlighted in biotech news updates.

Evolution of human intelligence linked to mental illness vulnerability

Researchers have traced genetic variants in the human genome to reveal that advances in cognitive abilities around 500,000 years ago were soon followed by mutations increasing susceptibility to psychiatric disorders. This suggests a trade-off in brain evolution. The study, published in Cerebral Cortex, analyzed 33,000 genetic variants to build an evolutionary timeline of brain-related traits.

CRISPR Tool Targets Neuron Gene Repair

15. september 2025 Rapportert av AI

Stanford researchers have created a CRISPR-based technology to target RNA in neurons, enabling repair processes for genetic diseases. The method addresses key challenges in Cas9 delivery and DNA repair. It reveals unique genome editing rules in neurons, paving the way for targeted therapies.

Study identifies potential genetic subtypes of autism

2. oktober 2025 Rapportert av AI

Researchers have proposed that autism spectrum disorder may consist of genetically distinct subtypes, based on an analysis of large-scale genetic data. This finding could lead to more personalized approaches to diagnosis and treatment. The study highlights variations in genetic markers among individuals with autism.