Many patients hesitate to stop antidepressants due to fears of withdrawal syndrome or symptom relapse. A study published in The Lancet shows that a gradual withdrawal, combined with psychological support, does not increase relapse risk compared to continuing the treatment.
Stopping antidepressants often poses a major challenge for patients with depressive or anxiety disorders. Many extend their treatment for years, fearing the return of symptoms or the effects of poorly managed withdrawal. A recent study, conducted by French experts and published on December 11, 2025, in The Lancet, provides reassuring insights on this issue.
The research compares two approaches: continuing the treatment and a gradual withdrawal accompanied by psychological support. The findings show that both methods are equally safe, with similar relapse risks. They are far preferable to an abrupt interruption or rapid dose reduction, which heighten complications.
Florian Naudet, professor at the University of Rennes and lead author of the study, states: “These two strategies – cautious withdrawal and continuing the treatment – are both safer than an abrupt interruption and a rapid reduction of antidepressants. Patients who are considering it should know that it is possible to stop, provided it is done within a shared decision with their doctor and with proper support.”
This publication highlights the importance of a shared decision between patient and physician, along with tailored support. It may encourage more individuals to consider a controlled withdrawal, while avoiding the pitfalls of a hasty cessation. The researchers emphasize the need for personalized follow-up to minimize risks associated with long-term treatments.
