克利夫兰守卫者队三垒手何塞·拉米雷斯在周六以3-1战胜底特律老虎队的比赛中，因左手钩骨骨折退场，并将进入伤病名单。另外两名先发球员也因伤提前离场。
本赛季首发了全部72场比赛的拉米雷斯在前进球场第六局上半离场。他在此役3打数1安打，贡献一支二垒安打并得到一分。
外野手蔡斯·德劳特和安赫尔·马丁内斯此前已先行退场。德劳特在第一局撞击右外野围墙后导致右侧肋骨挫伤。马丁内斯则因界外球击中左脚导致挫伤离场；X光检查结果为阴性。
守卫者队通过调整球员位置来应对空缺。凯尔·曼扎多替补出任一垒手，里斯·霍斯金斯移防至左外野，史蒂文·关改守中外野，丹尼尔·施内曼则接替防守三垒。
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The Cleveland Guardians defeated the Chicago Cubs 4-1 in their home opener on Friday at Progressive Field. Cubs starter Cade Horton left in the second inning with right forearm discomfort after his velocity dropped. Chase DeLauter went 3-for-4 with a two-run homer and three RBIs for Cleveland.
José Ramírez belted a pair of home runs to help the Cleveland Guardians defeat the Baltimore Orioles 8-4 at Progressive Field. The performance allowed the 33-year-old third baseman to pass Earl Averill for second place on the franchise's all-time home home run list at Progressive Field and other venues. Cleveland secured the four-game series victory.
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The Houston Astros ended an eight-game road losing streak with a 9-2 victory over the Cleveland Guardians on Monday night in Cleveland. Isaac Paredes hit two home runs, while Christian Walker added a two-run homer. Left fielder Taylor Trammell left the game with a left groin injury in the fourth inning.
Toronto Blue Jays outfielder Jesús Sánchez left Sunday's game against the Baltimore Orioles after being struck by a ball thrown from the stands at Camden Yards. The incident occurred during the sixth inning of a 9-5 Orioles win.
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Chase DeLauter delivered a bases-loaded triple in the eighth inning to rally the Cleveland Guardians to an 8-5 victory over the Houston Astros at Progressive Field. The hit erased a one-run deficit and snapped DeLauter's personal 0-for-12 skid. Brayan Rocchio extended his hitting streak to a career-high eight games in the win.
Cincinnati Reds starter Rhett Lowder left Thursday's game against the Chicago Cubs early due to right shoulder discomfort. The Cubs secured an 8-3 win at Wrigley Field to complete a four-game sweep.
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The Houston Astros placed shortstop Jeremy Peña on the 10-day injured list with a Grade 1 right hamstring strain and pitcher Tatsuya Imai on the 15-day injured list with right arm fatigue on Monday in Seattle. The moves exacerbate a seven-game losing streak and mounting pitching injuries, following Imai's return to Houston for testing after Friday's rough outing.