Gastroenterology
Study links dual colon polyps to higher risk of advanced precancerous changes
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Researchers from Flinders University and Flinders Medical Centre, reviewing more than 8,400 colonoscopy records, reported that people found to have both adenomas and serrated polyps had up to a fivefold higher risk of developing advanced precancerous colorectal changes at follow-up than those with only one polyp type.
A new study in Gastroenterology connects early life stress to long-term gut issues through disruptions in gut-brain communication. Mouse experiments and large human cohorts show links to pain, constipation, and irritable bowel syndrome. Researchers suggest targeted treatments based on specific biological pathways.
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Researchers at the Massachusetts Institute of Technology report that intelectin-2, a carbohydrate-binding lectin found in the gastrointestinal tract, can both crosslink mucus components to reinforce the gut’s protective barrier and bind certain bacteria, restricting their growth and reducing viability—findings that may inform future approaches to drug-resistant infections and inflammatory bowel disease.