Genetic analyses suggest swine fever virus did not escape from Catalan lab

Preliminary genetic analyses indicate that the African swine fever virus killing 29 wild boars in Barcelona did not originate from the nearby Generalitat laboratory. Scientists compared the DNA and found mutations suggesting years of separate evolution. However, the results are not conclusive, with further tests pending.

The scientific team led by Toni Gabaldón from the Barcelona Institute of Biomedical Research presented a preliminary report on Tuesday comparing the DNA of the virus found in wild boars with samples from the Animal Health Research Center (CReSA) in Bellaterra. The results show that the pathogen in the animals has a high number of mutations compared to those in the lab, which does not fit a recent escape. "They are strains of the same virus, but apparently separated by years of evolution, not days," the scientists explained.

The first infected wild boar carcass was found on November 25 just hundreds of meters from the CReSA, which was experimenting with the virus to develop a vaccine. The Ministry of Agriculture suggested a possible leak on December 5, leading to a raid on the lab by Mossos d'Esquadra and the Civil Guard on December 18. The virus belongs to a new genetic group, previously unknown, similar to the 2007 Georgia strain but with notable differences.

Agriculture Counselor Òscar Ordeig called for "prudence" in a press conference and highlighted the potential impact on Catalonia's agri-food sector, though 80% of countries have accepted export regionalization. Veterinarian Christian Gortázar from the Institute of Game Resources Research warned that all hypotheses remain open: "The only thing we know is that the virus does not match 19 CReSA samples. Ruling it out 100% is almost as hard as confirming it."

The CReSA, under construction since September, passed an external audit confirming its suitability for handling pathogens. Nineteen lab samples have been analyzed, with two pending. The outbreak has been contained to 29 wild boars, without affecting pig farms.

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Illustration of Catalan officials and farmers agreeing to cull healthy pigs on a farm near Barcelona amid African swine fever outbreak.
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Catalan government agrees to cull 30,000 healthy pigs over swine fever in Barcelona

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The Catalan government has reached an agreement with the farming sector to cull 30,000 healthy pigs on farms near the African swine fever outbreak detected in Barcelona's Collserola range. The measure, agreed upon in an urgent meeting on Friday, aims to prevent the spread of the outbreak and reassure a key economic sector. The meat from these animals will be used for internal consumption.

Two weeks after detecting an african swine fever outbreak in wild boars in Cerdanyola del Vallés, Barcelona—the first in Spain since 1994—questions about its origin remain unresolved. The hypothesis of a leak from a nearby laboratory experimenting with a modified virus for vaccine development is gaining traction. Authorities urge caution as 16 positives are confirmed in the affected area.

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The Catalan government has authorized a temporary employment regulation file (ERTE) affecting 458 meat sector workers in Santa Eugènia de Berga, due to an outbreak of African swine fever detected near Barcelona. The measure, requested by a temporary employment agency, is due to force majeure and allows the affected workers to access unemployment benefits.

Protests against France's bovine contagious nodular dermatosis (DNC) culling policy intensified on December 14 in southwest France, with a manure-strewn demonstration in Millau and ongoing highway blockades, as farmers demand alternatives to euthanizing healthy animals. The actions precede Agriculture Minister Annie Genevard's Monday visit to Occitanie amid veterinary backlash and calls for dialogue.

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Scientists from the universities of Cambridge and Glasgow have shown why many bird flu viruses can keep replicating at fever-like temperatures that typically curb human flu. A study in Science identifies the viral PB1 gene as crucial to this heat tolerance, raising concerns about pandemic risks if such genes move into human strains.

Cuba has a favorable epidemiological situation in its fight against arboviruses, following a 21 percent decrease in reported febrile cases last week. This improvement highlights effective efforts to control vector-borne diseases such as dengue and zika. Health authorities emphasize the need for ongoing vigilance.

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Virologist Xia Xian, a rising star in the field, has left the US to return to his alma mater, Wuhan University, as a full-time research professor and principal investigator. He will study viruses that can cause life-threatening diseases at a key biosafety lab. His work centers on structural biology of pathogenic microorganisms using advanced microscopy techniques.

 

 

 

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