Vaccines
DNA origami “DoriVac” shows strong immune activation in early tests, offering a potential complement to mRNA vaccines
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Researchers at Harvard’s Wyss Institute and Dana-Farber Cancer Institute report that a DNA origami-based vaccine platform called DoriVac generated robust immune responses in mice and in a human lymph node “Organ Chip” model. The team says the approach could be easier to store and manufacture than lipid nanoparticle–delivered mRNA vaccines, though the work remains preclinical. The results were published in Nature Biomedical Engineering.
Moderna confirmed ongoing work on an mRNA vaccine for hantavirus following a deadly outbreak on a Dutch cruise ship. The effort, in partnership with Korea University, began in 2023 and shows promise but remains years from completion.
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Dalarna's infection control unit has updated its advice following new recommendations from the Public Health Agency of Sweden. Residents in Borlänge, Säter, Avesta, Smedjebacken, Ludvika and Hedemora should now get vaccinated against TBE.
Researchers at Stanford Medicine have created an experimental nasal spray vaccine that protects mice against multiple respiratory threats, including COVID-19, flu, bacterial pneumonia, and allergens. The vaccine activates the lungs' innate immune system for months, offering broad defense without targeting specific pathogens. Published in Science on February 19, the study suggests potential for human trials soon.
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Researchers at Northwestern University have developed a more effective therapeutic vaccine for HPV-related cancers by rearranging components in a DNA-based nanoparticle. This structural adjustment significantly enhances the immune system's ability to target and destroy tumors. The findings, published in Science Advances, highlight the importance of molecular arrangement in vaccine design.
The measles vaccine has averted 60 million deaths worldwide since 2000, yet low vaccination rates fueled by misinformation are causing outbreaks in several countries. A fraudulent 1998 study linking the MMR vaccine to autism continues to undermine public health efforts. Experts urge stronger measures to counter anti-vaccine disinformation on social media and beyond.
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Measles infections in the United States hit their highest level in over three decades last year, with 2,242 confirmed cases. A surging outbreak in South Carolina, which has infected more than 600 people since October, threatens to surpass a major incident in West Texas. This development signals another challenging year for public health ahead.
Patients seek unvaccinated blood donations, causing treatment delays
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