Vaccines
AI-designed “pan-sarbecovirus” vaccine candidate reports early safety and immune-response signals in first human trial
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A needle-free, DNA-based vaccine candidate designed using machine-learning methods has completed a first-in-human Phase 1 study in the UK, with researchers reporting it was well tolerated and induced immune responses against multiple viruses in the sarbecovirus group, which includes SARS-CoV, SARS-CoV-2 and related bat coronaviruses.
A new study indicates that the phase of a woman's menstrual cycle at the time of COVID-19 vaccination may influence how soon breakthrough infections occur. Researchers found earlier infections among those vaccinated during the luteal phase compared with the follicular phase.
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Doctors in Tambaram organised an awareness rally on Saturday to promote the HPV vaccine for girls under 14.
Egypt's Ministry of Health aims to produce 140 million human vaccine doses annually by 2030 under its Vaccine City project. Health Minister Khaled Abdel Ghaffar reviewed the project's progress, emphasizing efforts for self-sufficiency and exports to regional and international markets.
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Scientists at Scripps Research have developed a nanodisc platform that mimics viral membranes, uncovering hidden interactions in HIV and Ebola proteins that traditional methods miss. The technology allows for more accurate study of antibody responses, potentially accelerating vaccine development. The findings appear in Nature Communications.
A new study suggests that the shingles vaccine may slow biological aging and reduce inflammation in older adults. Researchers analyzed data from over 3,800 Americans aged 70 and older, finding that vaccinated individuals showed better markers of aging compared to those who were not. The findings highlight potential broader health benefits from the vaccine beyond preventing the rash.
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Researchers at Stanford Medicine have created an experimental nasal spray vaccine that protects mice against multiple respiratory threats, including COVID-19, flu, bacterial pneumonia, and allergens. The vaccine activates the lungs' innate immune system for months, offering broad defense without targeting specific pathogens. Published in Science on February 19, the study suggests potential for human trials soon.
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