Vaccines
DNA origami “DoriVac” shows strong immune activation in early tests, offering a potential complement to mRNA vaccines
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Researchers at Harvard’s Wyss Institute and Dana-Farber Cancer Institute report that a DNA origami-based vaccine platform called DoriVac generated robust immune responses in mice and in a human lymph node “Organ Chip” model. The team says the approach could be easier to store and manufacture than lipid nanoparticle–delivered mRNA vaccines, though the work remains preclinical. The results were published in Nature Biomedical Engineering.
A new study found that the shingles vaccine reduced major cardiac events by 46% and deaths by 66% in people with atherosclerotic heart disease. The research, presented at the American College of Cardiology's Annual Scientific Session, examined over 246,000 US adults aged 50 and older.
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Dr. Vinay Prasad, who leads the FDA division that oversees vaccines and other biological products, will leave the agency at the end of April, FDA Commissioner Marty Makary told staff in an email. It will be Prasad’s second departure in less than a year after a brief exit last summer amid clashes over high-profile drug and vaccine reviews.
The measles vaccine has averted 60 million deaths worldwide since 2000, yet low vaccination rates fueled by misinformation are causing outbreaks in several countries. A fraudulent 1998 study linking the MMR vaccine to autism continues to undermine public health efforts. Experts urge stronger measures to counter anti-vaccine disinformation on social media and beyond.
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Measles infections in the United States hit their highest level in over three decades last year, with 2,242 confirmed cases. A surging outbreak in South Carolina, which has infected more than 600 people since October, threatens to surpass a major incident in West Texas. This development signals another challenging year for public health ahead.
Nature Medicine has selected promising clinical studies for 2026, emphasizing long-lasting vaccines and innovative treatments. Key areas include tuberculosis, HIV, long Covid, stem cells, and cholesterol. These developments could transform the fight against global diseases.
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Egypt has marked a milestone in biopharmaceutical development with the foundation stone laying for the Gennvax vaccine facility, set to be the largest integrated production complex in the Middle East and Africa. The project advances vaccine localization and national drug security. The ceremony drew senior officials and healthcare leaders.
Shingles vaccine associated with slower biological aging
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