Vaccines
DNA origami “DoriVac” shows strong immune activation in early tests, offering a potential complement to mRNA vaccines
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Researchers at Harvard’s Wyss Institute and Dana-Farber Cancer Institute report that a DNA origami-based vaccine platform called DoriVac generated robust immune responses in mice and in a human lymph node “Organ Chip” model. The team says the approach could be easier to store and manufacture than lipid nanoparticle–delivered mRNA vaccines, though the work remains preclinical. The results were published in Nature Biomedical Engineering.
Dalarna's infection control unit has updated its advice following new recommendations from the Public Health Agency of Sweden. Residents in Borlänge, Säter, Avesta, Smedjebacken, Ludvika and Hedemora should now get vaccinated against TBE.
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Fifteen patients at Vanderbilt University Medical Center in Nashville, Tennessee, requested blood transfusions from donors unvaccinated against covid-19, leading to dangerous delays in care. One patient suffered a life-threatening drop in haemoglobin levels. Researchers warn that such requests stem from misinformation despite the safety of the regulated blood supply.
Researchers at Northwestern University have developed a more effective therapeutic vaccine for HPV-related cancers by rearranging components in a DNA-based nanoparticle. This structural adjustment significantly enhances the immune system's ability to target and destroy tumors. The findings, published in Science Advances, highlight the importance of molecular arrangement in vaccine design.
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In a recent meeting with the Cuban president, health experts presented progress on the Finlay Vaccine Institute's pneumococcal conjugate vaccine development program. This effort, led for over 20 years, aims to protect children and older adults from severe diseases caused by Streptococcus pneumoniae. The heptavalent Quimi-Vio® vaccine is already registered and shows positive results in reducing mortality.
Measles infections in the United States hit their highest level in over three decades last year, with 2,242 confirmed cases. A surging outbreak in South Carolina, which has infected more than 600 people since October, threatens to surpass a major incident in West Texas. This development signals another challenging year for public health ahead.
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Egypt’s Ministry of Health and Population announced that the state-owned Holding Company for Biological Products and Vaccines (VACSERA) hosted a delegation from GenVax Egypt and China’s Minhai to accelerate efforts in localizing production of a key childhood vaccine. The visit aims to fast-track a “gap analysis” plan needed to activate an existing agreement between VACSERA and GenVax Egypt for domestic manufacturing of the pneumococcal conjugate vaccine (PCV13).
Egypt targets 140 million annual human vaccine doses by 2030
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