Researchers at Texas A&M University have developed a nasal spray that appears to reverse aspects of brain aging after just two doses. The treatment reduced inflammation and restored memory function in models for months afterward. The findings were published in the Journal of Extracellular Vesicles.
The experimental therapy uses extracellular vesicles loaded with microRNAs delivered through a nasal spray. This approach targets chronic inflammation in the brain known as neuroinflammaging and restores mitochondrial function in cells. Dr. Ashok Shetty led the team with Dr. Madhu Leelavathi Narayana and Dr. Maheedhar Kodali. The study received support from the National Institute on Aging and resulted in a filed U.S. patent.