Gene Editing
CRISPR knockout of NRF2 re-sensitizes drug‑resistant lung tumors in preclinical study
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Researchers at ChristianaCare’s Gene Editing Institute report that disabling the NRF2 gene with CRISPR restored chemotherapy sensitivity in models of squamous non‑small cell lung cancer and slowed tumor growth, with benefits seen even when only a fraction of tumor cells were edited. The work was published online November 13, 2025 in Molecular Therapy Oncology.
Researchers at Texas A&M University have developed a chemogenetic system that uses caffeine to activate CRISPR gene editing in cells, potentially aiding treatments for cancer and diabetes. The method allows precise control over gene modifications by consuming small amounts of caffeine from everyday sources like coffee or chocolate. This approach aims to enhance immune responses and insulin production with reversible activation.
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Chinese and Australian researchers used the CRISPR/Cas9 tool to silence two genes, creating a tomato that emits the aroma of buttered popcorn. The tomatoes appear ordinary but carry a surprisingly sweet scent reminiscent of premium fragrant rice. The study was published online on January 24 in the Journal of Integrative Agriculture.
Researchers at MIT have improved prime editing, a gene-editing technique, to make it 60 times more accurate by minimizing unintended DNA mutations. This advancement could enhance the safety of treatments for genetic diseases. The study, led by Vikash Chauhan, was published in Nature.
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New gene therapies are in development for conditions like follistatin-related disorders and other genetic issues, aiming to provide effective treatments without ongoing interventions. The pipeline includes therapies for muscle growth, hormone regulation, and tissue repair. This marks progress in precision medicine for rare and chronic diseases.