基因编辑
CRISPR knockout of NRF2 re-sensitizes drug‑resistant lung tumors in preclinical study
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Researchers at ChristianaCare’s Gene Editing Institute report that disabling the NRF2 gene with CRISPR restored chemotherapy sensitivity in models of squamous non‑small cell lung cancer and slowed tumor growth, with benefits seen even when only a fraction of tumor cells were edited. The work was published online November 13, 2025 in Molecular Therapy Oncology.
Researchers at Texas A&M University have developed a chemogenetic system that uses caffeine to activate CRISPR gene editing in cells, potentially aiding treatments for cancer and diabetes. The method allows precise control over gene modifications by consuming small amounts of caffeine from everyday sources like coffee or chocolate. This approach aims to enhance immune responses and insulin production with reversible activation.
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中国和澳大利亚研究人员利用CRISPR/Cas9工具沉默了两个基因，成功培育出一种散发爆米花香味的番茄。这种番茄外观普通，但散发着黄油爆米花的甜美香气。研究论文于1月24日在《农业整合杂志》在线发表。
Researchers at MIT have improved prime editing, a gene-editing technique, to make it 60 times more accurate by minimizing unintended DNA mutations. This advancement could enhance the safety of treatments for genetic diseases. The study, led by Vikash Chauhan, was published in Nature.
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New gene therapies are in development for conditions like follistatin-related disorders and other genetic issues, aiming to provide effective treatments without ongoing interventions. The pipeline includes therapies for muscle growth, hormone regulation, and tissue repair. This marks progress in precision medicine for rare and chronic diseases.