Study finds melanoma spreads most in middle age

31. toukokuuta 2026

Raportoinut AI

New research from Fox Chase Cancer Center shows that melanoma spreads more aggressively in middle-aged mice than in young or very old ones. The pattern appears linked to changes in a specific type of immune cell over time.

Researchers presented the findings at the American Association for Cancer Research annual meeting. Cancer spread reached its peak in middle-aged mice while remaining lower in young mice and declining again in very old mice. Mitchell Fane, the lead investigator, noted that most laboratory studies use only young mice, which limits understanding of how cancer behaves in older patients.

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Illustration of a mouse intestine cross-section comparing exosomes in young and old mice for aging research news.

Study links gut “luminal exosomes” to age-related inflammation and metabolic decline in mice

16. toukokuuta 2026 Raportoinut AI AI:n luoma kuva Faktatarkistettu

Researchers at Marshall University report that microscopic particles found in the gut lumen—known as exosomes—differ between young and old mice and can influence metabolism and gut-barrier function when transferred between animals. The findings, published in the journal Aging Cell, suggest these particles may help drive biological changes associated with aging, though the work is preclinical.

UCLA scientists reverse liver damage in mice by removing zombie cells

Researchers at UCLA have identified senescent immune cells, dubbed 'zombie' cells, that accumulate in aging livers and contribute to fatty liver disease. By eliminating these cells in mice, the team reversed liver damage and reduced body weight, even on an unhealthy diet. The findings, published in Nature Aging, suggest similar mechanisms may drive human liver conditions.

Mouse study suggests restoring a youthful gut microbiome may curb age-related liver damage and cancer risk

10. toukokuuta 2026 Raportoinut AI Faktatarkistettu

Researchers reported at Digestive Disease Week (DDW) 2026 that older mice given fecal microbiota transplants made from their own preserved, younger-age stool samples showed less liver inflammation and injury—and none developed liver cancer in the experiment.

Terveys

Study of nearly 500 cat tumors finds cancer-gene overlaps with humans and dogs

Terveys

Study finds olive oil fat speeds pancreatic cancer in mice

Tiede

Stiffening cancer cells boosts car t-cell therapy in mice

Johns Hopkins identifies KLF5 gene fueling pancreatic cancer spread

Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.

Study shows cloned mice accumulate harmful mutations

25. maaliskuuta 2026 Raportoinut AI

A 20-year experiment cloning mice has revealed that clones develop significantly more genetic mutations than naturally reproduced mice, accumulating to fatal levels after multiple generations. Researchers led by Teruhiko Wakayama at Yamanashi University in Japan found over 70 mutations per clone generation on average, three times higher than in controls. The findings, published in Nature Communications, raise concerns for applications in farming, conservation and de-extinction efforts.

4. kesäkuuta 2026 18.59

Study of young lung cancer patients finds unexpectedly high diet-quality scores; researchers probe possible pesticide exposure

3. huhtikuuta 2026 03.43

UCSF study explains severe flu and COVID in older adults

21. maaliskuuta 2026 16.37