Une étude révèle que le mélanome se propage davantage à l'âge mûr

De nouvelles recherches du Fox Chase Cancer Center montrent que le mélanome se propage de manière plus agressive chez les souris d'âge mûr que chez les souris jeunes ou très âgées. Ce phénomène semble lié à l'évolution, au fil du temps, d'un type spécifique de cellule immunitaire.

Les chercheurs ont présenté ces résultats lors de la réunion annuelle de l'American Association for Cancer Research. La propagation du cancer a atteint son pic chez les souris d'âge mûr, tandis qu'elle est restée plus faible chez les souris jeunes et a de nouveau décliné chez les souris très âgées. Mitchell Fane, le chercheur principal, a souligné que la plupart des études en laboratoire n'utilisent que des souris jeunes, ce qui limite la compréhension du comportement du cancer chez les patients plus âgés.

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Researchers at Marshall University report that microscopic particles found in the gut lumen—known as exosomes—differ between young and old mice and can influence metabolism and gut-barrier function when transferred between animals. The findings, published in the journal Aging Cell, suggest these particles may help drive biological changes associated with aging, though the work is preclinical.

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