Studi menemukan melanoma paling cepat menyebar pada usia paruh baya

Penelitian terbaru dari Fox Chase Cancer Center menunjukkan bahwa melanoma menyebar lebih agresif pada tikus usia paruh baya dibandingkan tikus muda atau yang sudah sangat tua. Pola ini tampaknya terkait dengan perubahan pada jenis sel kekebalan tertentu seiring berjalannya waktu.

Para peneliti memaparkan temuan tersebut pada pertemuan tahunan American Association for Cancer Research. Penyebaran kanker mencapai puncaknya pada tikus usia paruh baya, sementara tetap rendah pada tikus muda dan menurun kembali pada tikus yang sudah sangat tua. Mitchell Fane, penyelidik utama, mencatat bahwa sebagian besar studi laboratorium hanya menggunakan tikus muda, yang membatasi pemahaman tentang bagaimana perilaku kanker pada pasien yang lebih tua.

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Illustration of a mouse intestine cross-section comparing exosomes in young and old mice for aging research news.
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Study links gut “luminal exosomes” to age-related inflammation and metabolic decline in mice

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Researchers at Marshall University report that microscopic particles found in the gut lumen—known as exosomes—differ between young and old mice and can influence metabolism and gut-barrier function when transferred between animals. The findings, published in the journal Aging Cell, suggest these particles may help drive biological changes associated with aging, though the work is preclinical.

Researchers at UCLA have identified senescent immune cells, dubbed 'zombie' cells, that accumulate in aging livers and contribute to fatty liver disease. By eliminating these cells in mice, the team reversed liver damage and reduced body weight, even on an unhealthy diet. The findings, published in Nature Aging, suggest similar mechanisms may drive human liver conditions.

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Researchers reported at Digestive Disease Week (DDW) 2026 that older mice given fecal microbiota transplants made from their own preserved, younger-age stool samples showed less liver inflammation and injury—and none developed liver cancer in the experiment.

Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.

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A 20-year experiment cloning mice has revealed that clones develop significantly more genetic mutations than naturally reproduced mice, accumulating to fatal levels after multiple generations. Researchers led by Teruhiko Wakayama at Yamanashi University in Japan found over 70 mutations per clone generation on average, three times higher than in controls. The findings, published in Nature Communications, raise concerns for applications in farming, conservation and de-extinction efforts.

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