フォックス・チェースがんセンターの新たな研究により、メラノーマは若年や高齢のマウスに比べ、中年期マウスにおいてより攻撃的に転移することが明らかになった。このパターンは、特定の免疫細胞が時間とともに変化することに関連しているとみられる。
研究者らは、米国がん学会の年次総会でこの調査結果を発表した。がんの転移は中年マウスでピークに達する一方、若年マウスでは低く抑えられ、高齢マウスでは再び減少した。主任研究員のミッチェル・フェイン氏は、ほとんどの実験室研究が若年マウスのみを使用しているため、高齢の患者におけるがんの挙動についての理解が限定されていると指摘した。
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Researchers at Marshall University report that microscopic particles found in the gut lumen—known as exosomes—differ between young and old mice and can influence metabolism and gut-barrier function when transferred between animals. The findings, published in the journal Aging Cell, suggest these particles may help drive biological changes associated with aging, though the work is preclinical.
Researchers at UCLA have identified senescent immune cells, dubbed 'zombie' cells, that accumulate in aging livers and contribute to fatty liver disease. By eliminating these cells in mice, the team reversed liver damage and reduced body weight, even on an unhealthy diet. The findings, published in Nature Aging, suggest similar mechanisms may drive human liver conditions.
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Researchers reported at Digestive Disease Week (DDW) 2026 that older mice given fecal microbiota transplants made from their own preserved, younger-age stool samples showed less liver inflammation and injury—and none developed liver cancer in the experiment.
Scientists at Johns Hopkins Medicine have pinpointed the gene KLF5 as a key driver of pancreatic cancer metastasis through epigenetic changes rather than DNA mutations. Using CRISPR technology, researchers found that KLF5 promotes tumor growth and invasion by altering DNA packaging and activating other cancer-related genes. The findings, published in Molecular Cancer, suggest potential new treatment targets.
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A 20-year experiment cloning mice has revealed that clones develop significantly more genetic mutations than naturally reproduced mice, accumulating to fatal levels after multiple generations. Researchers led by Teruhiko Wakayama at Yamanashi University in Japan found over 70 mutations per clone generation on average, three times higher than in controls. The findings, published in Nature Communications, raise concerns for applications in farming, conservation and de-extinction efforts.