A scientist in a lab analyzing a blood sample for early Alzheimer's detection, with brain scan overlays.
A scientist in a lab analyzing a blood sample for early Alzheimer's detection, with brain scan overlays.
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Blood test can reveal Alzheimer's signs years ahead

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A new study shows that blood tests can detect signs of Alzheimer's several years before the disease develops. American researchers published the findings in The Lancet.

American researchers examined blood samples from 1 350 people without dementia with a mean age of 61 in a study published in The Lancet. Levels of the protein phosphorylated tau were found to rise already in the 60s.

86 participants had elevated levels and performed worse on cognitive tests. These individuals also declined faster at follow-ups every five years.

Henrik Zetterberg at the University of Gothenburg says the blood test is simpler than current methods. He stresses there is no reason for broad testing today since effective treatments are lacking in Sweden.

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Illustration of mutated blood cells entering the brain through the blood-brain barrier, linked to Alzheimer's pathology.
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Study finds blood-cancer-linked mutations in brain immune cells tied to Alzheimer’s pathology

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Researchers at Boston Children’s Hospital report that mutations commonly associated with clonal blood-cell expansion and some blood cancers were enriched in microglia-like immune cells in Alzheimer’s brains and were also detectable in matched blood samples. The Cell study proposes that age- or injury-related weakening of the blood-brain barrier could allow mutated blood immune cells to enter the brain, potentially amplifying inflammation and contributing to neurodegeneration.

Women maintain normal scores on standard memory tests for nearly three years longer than men even after Alzheimer’s-related brain changes begin. This cognitive advantage can mask early signs of the disease and delay treatment. A new analysis of long-term studies in the US and Canada highlights the issue.

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A new study has found that adults with higher vitamin D levels in their 30s and 40s tend to have lower levels of tau protein in their brains about 16 years later. Tau is a key biomarker associated with dementia. The research, published this week, highlights a potential modifiable risk factor for brain health.

Researchers at Cold Spring Harbor Laboratory have found that blocking the protein PTP1B improves memory and boosts plaque clearance in mouse models of Alzheimer's disease. The discovery links the protein to brain immune function and metabolic risks like diabetes and obesity. The team aims to develop inhibitors for potential human treatments.

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A copper-based drug has shown potential to reduce toxic protein buildup and improve memory in laboratory models of Alzheimer’s disease. Researchers at Monash University found that the compound Cu(ATSM) enhanced the brain’s waste-clearing mechanisms. The results were published in ACS Chemical Neuroscience.

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