Illustration of a doctor discussing positive kidney treatment results with a patient using digital graphs.
Illustration of a doctor discussing positive kidney treatment results with a patient using digital graphs.
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Finerenone slows kidney decline in non-diabetic CKD trial; pooled analysis suggests broader benefits across CKD

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An Binciki Gaskiya

New data presented at the European Renal Association’s 63rd Congress in Glasgow and published in three major medical journals found that finerenone slowed kidney-function decline in adults with chronic kidney disease (CKD) without diabetes and reduced the risk of a combined kidney-and-cardiovascular outcome. A separate pooled analysis that combined results across finerenone studies also reported fewer kidney and heart-failure events in a broader CKD population.

Researchers reported the results at the European Renal Association (ERA) 63rd Congress in Glasgow, Scotland, with simultaneous publications tied to the presentations in The New England Journal of Medicine, JAMA and The Lancet.

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Initial reactions on X highlight positive findings from the FIND-CKD trial showing finerenone slows eGFR decline in non-diabetic CKD patients, with 23% risk reduction in kidney and CV events, and similar benefits in pooled analyses across broader CKD populations. Medical professionals and journals express enthusiasm for expanded indications beyond diabetes.

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Clinical illustration of nurse giving single-dose zilebesiran injection to hypertension patient, with blood pressure monitor showing reduction from KARDIA-2 trial results.
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Single-dose zilebesiran as add-on therapy lowers systolic blood pressure in KARDIA-2 trial

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A single, under-the-skin dose of the investigational RNA-interference drug zilebesiran lowered blood pressure when added to standard therapy in adults whose hypertension remained uncontrolled, according to results from the global Phase 2 KARDIA-2 trial of 663 participants published in JAMA.

The U.S. Food and Drug Administration approved FILSPARI, developed by Travere Therapeutics, as the first medicine for focal segmental glomerulosclerosis (FSGS). Travere announced the approval on April 13, 2026. Company executives held a business update conference call that evening to discuss the milestone.

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Researchers in Barcelona report that the lipid drug pemafibrate and the blood-pressure medicine telmisartan reduced diet-induced liver fat in rats and in a zebrafish model of fatty liver disease, with a half-dose combination performing as well as full doses of either drug alone. The work, published in Pharmacological Research, also describes a role for the PCK1 protein in telmisartan’s liver effects and argues that clinical trials would be needed to confirm any benefit in people.

A randomized, placebo-controlled trial led by Australia’s Garvan Institute of Medical Research found that metformin, a long-used and low-cost drug for type 2 diabetes, did not improve clamp-measured insulin resistance in adults with type 1 diabetes but was associated with roughly 12% lower insulin requirements while blood sugar measures remained broadly unchanged.

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Researchers from Mass General Brigham found that the cholesterol drug evolocumab cuts the risk of first-time major cardiovascular events by 31% in high-risk patients with diabetes who lack diagnosed atherosclerosis. The results, from a subgroup analysis of the VESALIUS-CV trial, were presented at the American College of Cardiology's Annual Scientific Session and published in JAMA. Patients on the drug saw LDL cholesterol levels drop significantly alongside standard treatments.

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