Immunology
Electrical stimulation reprograms human immune cells to spur repair
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Trinity College Dublin researchers report that electrically stimulating human macrophages shifted them toward an anti‑inflammatory, tissue‑repairing state in laboratory tests, pointing to potential therapies for injuries and inflammatory disease. The peer‑reviewed findings appear in Cell Reports Physical Science.
Next-generation mRNA vaccines aim for stronger immune responses
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Scientists have developed mRNA vaccines that produce virus-like nanoparticles inside cells, potentially offering more robust immune responses than current versions. In mouse studies, this approach generated antibody levels up to 28 times higher than standard mRNA vaccines. The innovation could reduce side effects by allowing lower doses while maintaining efficacy.
Immune protein promotes arrhythmias after heart attacks
Researchers at Massachusetts General Hospital have identified an immune protein that damages heart cells after a myocardial infarction, leading to dangerous arrhythmias. By targeting this protein in mice, the team reduced arrhythmia incidents twelvefold. The findings suggest new ways to prevent sudden cardiac death.
First mRNA Therapy for ISG15 Deficiency Developed
Researchers developed the first experimental mRNA-based therapy for ISG15 deficiency, a rare genetic mutation providing near-universal viral immunity, as reported on September 9, 2025.
Cellular Treatment Outperforms Chemo in Cancer Models
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A new treatment tested in brain organoids with glioblastoma outperformed chemotherapy and dramatically reduced tumors in mice. Human trials are upcoming. The approach also explores stem cell stimulation and aging cell rejuvenation for broader immunotherapy applications.
Breastfeeding boosts immune cells that may prevent breast cancer
A new study reveals that breastfeeding leads to a long-term surge in specialized immune cells in breast tissue, potentially reducing cancer risk. Researchers found these CD8+ T cells persist for decades, acting as guards against malignant cells. The findings suggest breastfeeding could enhance natural protection against aggressive breast cancers.