Immunology
Electrical stimulation reprograms human immune cells to spur repair
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Trinity College Dublin researchers report that electrically stimulating human macrophages shifted them toward an anti‑inflammatory, tissue‑repairing state in laboratory tests, pointing to potential therapies for injuries and inflammatory disease. The peer‑reviewed findings appear in Cell Reports Physical Science.
Cellular Treatment Outperforms Chemo in Cancer Models
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A new treatment tested in brain organoids with glioblastoma outperformed chemotherapy and dramatically reduced tumors in mice. Human trials are upcoming. The approach also explores stem cell stimulation and aging cell rejuvenation for broader immunotherapy applications.
First mRNA Therapy for ISG15 Deficiency Developed
Researchers developed the first experimental mRNA-based therapy for ISG15 deficiency, a rare genetic mutation providing near-universal viral immunity, as reported on September 9, 2025.
Nobel prize in medicine awarded to trio for immune tolerance work
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The 2025 Nobel prize in physiology or medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a key immune cell that prevents the body from attacking itself. Their work revealed regulatory T-cells and the FOXP3 gene's role in controlling autoimmune responses. This breakthrough has opened new avenues for treating autoimmune diseases and cancers.
Next-generation mRNA vaccines aim for stronger immune responses
Scientists have developed mRNA vaccines that produce virus-like nanoparticles inside cells, potentially offering more robust immune responses than current versions. In mouse studies, this approach generated antibody levels up to 28 times higher than standard mRNA vaccines. The innovation could reduce side effects by allowing lower doses while maintaining efficacy.
Glioblastoma erodes skull and disrupts immune system, study reveals
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Researchers have discovered that glioblastoma, the most aggressive form of brain cancer, extends beyond the brain by eroding the skull and altering the immune cells in skull marrow. This interaction fuels the cancer's progression and explains why current treatments often fail. The findings, published in Nature Neuroscience, suggest new strategies targeting both brain and bone.