Glioblastoma erodes skull and disrupts immune system, study reveals

7 октября 2025 Сообщено ИИ

Researchers have discovered that glioblastoma, the most aggressive form of brain cancer, extends beyond the brain by eroding the skull and altering the immune cells in skull marrow. This interaction fuels the cancer's progression and explains why current treatments often fail. The findings, published in Nature Neuroscience, suggest new strategies targeting both brain and bone.

Cellular Treatment Outperforms Chemo in Cancer Models

15 сентября 2025 Сообщено ИИ

A new treatment tested in brain organoids with glioblastoma outperformed chemotherapy and dramatically reduced tumors in mice. Human trials are upcoming. The approach also explores stem cell stimulation and aging cell rejuvenation for broader immunotherapy applications.

Nobel prize in medicine awarded to trio for immune tolerance work

7 октября 2025 Сообщено ИИ

The 2025 Nobel prize in physiology or medicine has been awarded to Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi for discovering a key immune cell that prevents the body from attacking itself. Their work revealed regulatory T-cells and the FOXP3 gene's role in controlling autoimmune responses. This breakthrough has opened new avenues for treating autoimmune diseases and cancers.

First mRNA Therapy for ISG15 Deficiency Developed

Researchers developed the first experimental mRNA-based therapy for ISG15 deficiency, a rare genetic mutation providing near-universal viral immunity, as reported on September 9, 2025.