Dementia
Genetic study links lower cholesterol to reduced dementia risk
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A large-scale genetic analysis of about 1.09 million people suggests that lifelong, genetically lower cholesterol—specifically non‑HDL cholesterol—is associated with substantially reduced dementia risk. Using Mendelian randomization to emulate the effects of cholesterol‑lowering drug targets such as those for statins (HMGCR) and ezetimibe (NPC1L1), the study found up to an approximately 80% lower risk per 1 mmol/L reduction for some targets. ([research-information.bris.ac.uk](https://research-information.bris.ac.uk/en/publications/cholesterollowering-drug-targets-reduce-risk-of-dementia-mendelia?utm_source=openai))
Study overturns idea that light drinking protects brain health
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A large-scale study combining observational and genetic data has found that any alcohol consumption increases dementia risk, with no safe level identified. Published in BMJ Evidence Based Medicine, the research challenges previous beliefs about moderate drinking's benefits. Dementia risk rises linearly with alcohol intake, according to the analysis.
Northwestern study uncovers why superagers retain youthful memories
Researchers at Northwestern University have spent 25 years studying SuperAgers—people over 80 with memories as sharp as those 30 years younger—revealing key brain traits that resist cognitive decline. Their findings, published in a new perspective article, highlight two protective mechanisms against Alzheimer's-related damage and emphasize the role of social connections. The work could lead to new strategies for preventing dementia.
Online brain training tied to decade‑equivalent boost in cholinergic function, McGill trial finds
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A double‑blind McGill University–led clinical trial reports that 10 weeks of BrainHQ exercises increased a PET marker of cholinergic function in healthy older adults by an amount the authors say roughly offsets about a decade of age‑related decline. The peer‑reviewed study used a specialized tracer to confirm the biochemical change.
Study debunks link between calcium supplements and dementia
New research from Australian universities shows that calcium supplements do not increase dementia risk in older women. The findings, based on a long-term study of over 1,400 participants, counter earlier concerns about cognitive effects. Experts say the results reassure users taking calcium for osteoporosis prevention.
Study associates hearing aids with lower dementia risk
A large-scale study using UK Biobank data has found that adults with hearing loss who regularly use hearing aids face a significantly reduced risk of developing dementia. The research, published in The Lancet Healthy Longevity, highlights hearing loss treatment as a potential modifiable factor in dementia prevention. This comes amid growing evidence linking untreated hearing impairment to cognitive decline.