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Experts flag shingles vaccine, sildenafil and riluzole as leading Alzheimer’s repurposing candidates
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A University of Exeter-led study funded by Alzheimer’s Society has identified three already-approved medicines—the shingles vaccine Zostavax, sildenafil (Viagra) and riluzole—as top “priority” candidates to be tested in clinical trials for Alzheimer’s disease, after a structured review of 80 existing drugs by an international expert panel.
A study of over 375,000 Finns has linked hospital treatment for severe infections like cystitis and pneumonia to a higher risk of developing dementia within five to six years. Researchers identified 29 conditions associated with at least a 20 percent increased risk, with infections playing a key role. The findings suggest that preventing such infections could help modify dementia risk.
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High meat intake may reduce dementia risk for older people with genetic predisposition to Alzheimer's, per a Karolinska Institutet study. The study tracked over 2,100 individuals aged 60 and older for up to 15 years. Findings apply to carriers of specific apoe gene variants.
A long-term analysis of more than 200,000 UK Biobank participants found that diets with lower glycemic index values were associated with a lower risk of dementia, including Alzheimer’s disease and vascular dementia, while higher dietary glycemic load was tied to a higher risk.
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A new study reveals that despite guidelines, about one in four Medicare beneficiaries with dementia continue to receive brain-altering medications linked to falls and confusion. Prescribing rates have declined overall from 20% to 16% between 2013 and 2021, but those with cognitive impairment face higher risks. Researchers highlight the need for better documentation and alternatives to improve care safety.
Prof KVS Hari, director of the Centre for Brain Research at IISc Bengaluru, emphasized digital biomarkers for early detection and prevention of dementia. He noted that India's rapidly aging population makes dementia a major public health challenge. The centre focuses on data collection and AI to understand disease progression in the Indian context.
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阿尔茨海默病试验正转向受癌症研究启发的多靶点方法,即便Novo Nordisk的司美格鲁肽试验失败。只有两种药物——Eli Lilly的Kisunla和Eisai与Biogen的Leqembi——被广泛批准用于减缓疾病进展。这种演变将这种脑部退化疾病视为复杂系统,在其全球影响下寻求新的遏止途径。
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