Stem Cells
USC researchers begin early trial of dopamine-producing stem cell implants for Parkinson’s
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Keck Medicine of USC researchers are testing an experimental approach to Parkinson’s disease that implants lab-grown, dopamine-producing cells into a movement-control region of the brain. The early-stage Phase 1 REPLACE trial involves up to 12 people with moderate to moderate-severe Parkinson’s disease, and the U.S. Food and Drug Administration has granted the study fast-track designation.
Researchers in Sweden have created insulin-producing cells from human stem cells that reversed diabetes symptoms when transplanted into mice. The cells matured after placement in the eye and maintained glucose regulation for months. The work was published in Stem Cell Reports.
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An experimental therapy using stem cells from young donors has shown promise in improving mobility for frail older people. In a trial involving 148 participants, infusions of laromestrocel led to significant gains in walking distance. Researchers highlight its potential to address biological roots of frailty.
Researchers at Osaka Metropolitan University report that stem cells taken from body fat, formed into bone-leaning spheroids and paired with a common bone-reconstruction material, improved healing and strength in rat models of osteoporotic vertebral fractures. The preclinical findings, published in Bone & Joint Research, point to a potential future therapy if validated in humans.
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A Stanford Medicine team reports that a single dose of the anti‑CD117 antibody briquilimab allowed three children with Fanconi anemia to undergo stem cell transplants without radiation or busulfan, achieving near‑complete donor cell engraftment in a phase 1b study published in Nature Medicine.
Researchers at Cedars-Sinai have developed young immune cells from human stem cells that reversed signs of aging and Alzheimer's disease in mice. The treatment improved memory and brain structure in the animals. The findings, published in Advanced Science, suggest potential for personalized therapies against cognitive decline.
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Researchers at MIT have discovered that the amino acid cysteine can enhance the small intestine's ability to heal itself. In experiments with mice, a cysteine-rich diet activated immune cells to promote tissue regeneration after damage from radiation or chemotherapy. The findings, published in Nature, suggest potential dietary strategies to mitigate treatment side effects.
USC-led trial tests dopamine-producing stem cell implants for Parkinson’s
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