Stem Cells
UBC researchers show how to reliably generate helper T cells from stem cells by tuning Notch signaling
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Scientists at the University of British Columbia report a method to consistently produce human helper T cells from pluripotent stem cells by carefully adjusting the timing of a developmental signal known as Notch. The work, published in Cell Stem Cell, is positioned as a step toward scalable “off-the-shelf” immune-cell therapies for cancer and other diseases.
Scientists at the University of Southern California are starting a phase 2b clinical trial to test a microscopic stem cell implant aimed at restoring vision in patients with advanced dry age-related macular degeneration. The hair-thin patch seeks to replace damaged retinal cells, building on earlier research that showed safety and vision gains in some participants. Researchers hope it could offer a way to reverse vision loss where current treatments fall short.
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Researchers at Nagoya University in Japan have developed miniature brain models using stem cells to study interactions between the thalamus and cortex. Their work reveals the thalamus's key role in maturing cortical neural networks. The findings could advance research into neurological disorders like autism.
Planarian flatworms regenerate lost body parts using stem cells steered by signals from far‑off tissues rather than nearby neighbors, research published in Cell Reports on October 15, 2025, suggests—reframing how niches regulate stem cells and hinting at future approaches to tissue repair.
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A large clinical trial has shown that infusing mesenchymal stem cells from umbilical cord blood shortly after a first heart attack reduces the risk of developing heart failure by nearly 60 percent over three years. The treatment, administered within three to seven days, also improved heart pumping function compared to standard care. Researchers from Shiraz University in Iran led the study, providing strong evidence for stem cells' regenerative potential.
Researchers at Oregon Health and Science University have successfully generated functional human egg cells from skin cells, which were then fertilized in the lab to produce early-stage embryos. This breakthrough, published in Nature, represents the first time such eggs have been matured and used for fertilization outside the body. The technique could eventually aid infertility treatments and genetic disease prevention.
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StemDAO is developing therapies using extracellular vesicles from stem cells to address soft tissue injuries, cognitive decline, and aging. Clinical data shows benefits in cognition, skin health, and inflammation reduction. This approach triggers natural regeneration without surgery.