Stem Cells

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Illustration of USC researchers preparing dopamine-producing stem cell implants for early-stage Parkinson’s trial.
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USC researchers begin early trial of dopamine-producing stem cell implants for Parkinson’s

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Keck Medicine of USC researchers are testing an experimental approach to Parkinson’s disease that implants lab-grown, dopamine-producing cells into a movement-control region of the brain. The early-stage Phase 1 REPLACE trial involves up to 12 people with moderate to moderate-severe Parkinson’s disease, and the U.S. Food and Drug Administration has granted the study fast-track designation.

An experimental therapy using stem cells from young donors has shown promise in improving mobility for frail older people. In a trial involving 148 participants, infusions of laromestrocel led to significant gains in walking distance. Researchers highlight its potential to address biological roots of frailty.

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Doctors at Keck Medicine of USC are implanting lab-grown, dopamine-producing cells into the brains of people with Parkinson’s disease in an early-stage clinical trial that will enroll up to 12 participants across three U.S. sites.

A Stanford Medicine team reports that a single dose of the anti‑CD117 antibody briquilimab allowed three children with Fanconi anemia to undergo stem cell transplants without radiation or busulfan, achieving near‑complete donor cell engraftment in a phase 1b study published in Nature Medicine.

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Rockefeller University scientists report that, in mice, hair follicle stem cells switch from fueling hair growth to repairing wounds when the amino acid serine is scarce — a shift governed by the integrated stress response. The peer‑reviewed findings in Cell Metabolism suggest dietary or drug strategies could eventually help speed wound healing.

Researchers at MIT have discovered that the amino acid cysteine can enhance the small intestine's ability to heal itself. In experiments with mice, a cysteine-rich diet activated immune cells to promote tissue regeneration after damage from radiation or chemotherapy. The findings, published in Nature, suggest potential dietary strategies to mitigate treatment side effects.

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Researchers at Stanford University have developed a method to grow thousands of identical brain organoids using xanthan gum, a common food additive, to prevent them from sticking together. This breakthrough, led by Sergiu Pasca and Sarah Heilshorn, enables large-scale testing for brain development and drug screening. The technique could advance studies on disorders like autism and schizophrenia.

 

 

 

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