Longevity startup doses first patient in vision loss trial

A longevity startup has administered its first dose of a cellular rejuvenation therapy to a patient. The move follows recent FDA approval for human clinical trials of the treatment known as ER-100.

The therapy targets age-related sight loss as its initial focus. Company officials confirmed the dosing took place after regulators cleared the drug for trials. Vision restoration is the primary goal at this stage. The treatment may later address other conditions tied to aging. This marks an early step in efforts to apply cellular rejuvenation methods in people. The startup has not released details on the patient's condition or trial location.

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Scientist in lab studying mouse with DNA and brain inflammation overlays representing Alzheimer’s drug research.
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Experimental drug reduced DNA damage and inflammation in an Alzheimer’s mouse model, King’s College London says

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Scientists at King’s College London report that an experimental compound, KCL-286, repaired markers of DNA damage and lowered brain inflammation in a mouse model of Alzheimer’s disease. The team says the drug—originally developed for spinal cord injury—has already completed Phase 1 safety and tolerability testing in humans, which could speed plans for further clinical studies.

A US company plans to offer an unapproved gene therapy designed to boost levels of an anti-ageing protein called klotho. The treatment will be provided at clinics in Honduras, the Bahamas and Panama. It aims to bypass US regulatory requirements.

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A widely studied anti-aging treatment triggered significant brain damage in mice, according to new research from the University of Connecticut. The drug combination dasatinib plus quercetin caused myelin loss and changes resembling those seen in multiple sclerosis. The findings raise questions about its use in longevity studies and off-label therapies.

Researchers have shown that rejuvenating muscle stem cells from old mice leads to larger muscle growth and improved recovery after injury. The approach could one day help older people regain strength and mobility. Experiments demonstrated clear benefits in leg function and tissue repair.

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