Scientists discover internal winds in cells linked to cancer spread

Researchers at Oregon Health & Science University have identified hidden fluid flows inside cells that rapidly transport proteins to the leading edge, challenging traditional views of cellular movement. The discovery, made during a classroom experiment, could explain why some cancer cells spread aggressively. The findings appear in Nature Communications.

Catherine Galbraith and James Galbraith, researchers at Oregon Health & Science University, uncovered the cellular mechanism while leading a neurobiology course at the Marine Biological Laboratory in Massachusetts. Using a laser to track protein movement, they observed an unexpected dark band of soluble actin racing to the cell's front edge. 'We kind of did it for fun and then realized this gave us a way of measuring something that wasn't able to be measured before,' Cathy Galbraith said. This revealed directed fluid flows, likened to trade winds, that propel proteins faster than random diffusion alone would allow. James Galbraith added, 'Cells really do go with the flow.'

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Realistic microscopic illustration of cancer and epithelial cells sensing distant tissue features via collagen matrix, highlighting research on extended cellular reach and metastasis.
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Cells can sense 10 times farther than expected, a finding that may shed light on cancer spread

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Engineers at Washington University in St. Louis report that while single abnormal cells can mechanically probe roughly 10 microns beyond what they directly touch, groups of epithelial cells can combine forces through collagen to sense features more than 100 microns away—an effect the researchers say could help explain how cancer cells navigate tissue.

Scientists at Arizona State University have identified two unexpected ways bacteria can spread without their usual flagella structures. In one study, E. coli and salmonella use sugar fermentation to create fluid currents for surface migration, dubbed 'swashing.' A separate study reveals a molecular 'gearbox' in flavobacteria that controls directional movement.

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Scientists have proposed a theoretical model explaining how living cells could produce their own electrical signals through tiny movements in their membranes. This mechanism, driven by active molecular processes, might mimic neuronal activity and influence ion transport. The findings could inform bio-inspired materials and deepen understanding of cellular functions.

Researchers have developed a genomic mapping technique that reveals how thousands of genes work together to influence disease risk, helping to bridge gaps left by traditional genetic studies. The approach, described in a Nature paper led by Gladstone Institutes and Stanford University scientists, combines large-scale cell experiments with population genetics data to highlight promising targets for future therapies and deepen understanding of conditions such as blood disorders and immune-mediated diseases.

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Researchers at the University of Waterloo have developed engineered bacteria designed to invade and eat solid tumors from the inside out. The approach uses microbes that thrive in oxygen-free environments, targeting the low-oxygen cores of tumors. A genetic modification allows the bacteria to survive near oxygenated edges, controlled by a quorum-sensing mechanism.

Researchers at Harvard University have identified what may be a network of lymphatic-like vessels inside the brain that could help remove waste fluid. The finding, made while studying Alzheimer's disease in mice, raises possibilities for understanding neurodegenerative conditions. If confirmed, it could shift how scientists view brain function and diseases like Alzheimer's.

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Researchers at The Rockefeller University and Memorial Sloan Kettering Cancer Center have revealed a hidden spring‑like motion in the T cell receptor that helps trigger immune responses. Observed with cryo‑electron microscopy in a native‑like membrane environment, the mechanism may help explain why some T cell–based immunotherapies succeed while others fall short, and could inform efforts to make such treatments work for more patients.

 

 

 

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