Study links high-fat cheese to lower dementia risk

A Swedish study suggests that consuming more high-fat cheese could lower dementia risk by 13%, based on data from nearly 30,000 people followed for 25 years. However, experts caution that it is an observational analysis without proof of causality. Critics highlight potential confounders and the importance of factors like blood pressure and weight control.

A new study published in the journal Neurology analyzes data from 27,670 people in Sweden, with an average age of 58 at the start. Participants recorded their diet for a week and were followed for 25 years, during which 3,208 developed dementia. After adjusting for variables like age, sex, education, and overall diet quality, researchers found that those consuming more cheese with over 20% fat—such as manchego, parmesan, roquefort, or cheddar—had a 13% lower risk of dementia compared to those consuming less.

Emily Sonestedt, epidemiologist at Lund University and lead author, stated: “For decades, the debate on high-fat versus low-fat diets has shaped health advice, even categorizing cheese as an unhealthy food to limit. Our study discovered that some high-fat dairy products may actually reduce dementia risk, challenging entrenched assumptions about brain health”.

However, experts like Naveed Sattar from the University of Glasgow criticize the study for not proving causality and for potential confounders, such as higher education levels among cheese consumers. “We already know several well-established and proven factors that reduce dementia risk, like maintaining healthy blood pressure, controlling weight, and preventing heart disease or strokes. These interventions should remain the priority,” Sattar asserts.

Tara Spires-Jones from the University of Edinburgh adds that diets change over time and there is no solid evidence that a specific food protects against dementia. Dementia affected 57 million people in 2019 and could reach 153 million by 2050. A Lancet Commission report indicates that 45% of cases could be prevented by eliminating 14 risks, including excess LDL cholesterol, which accounts for 7% and is linked to strokes and Alzheimer's proteins. A meta-analysis from Peking University associates saturated fats with greater cognitive decline, though with methodological caution.

Experts stress that most dementia factors, like age and genetics, are beyond individual control, and there is no causal evidence of prevention through diet.

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Illustration of scientists analyzing genetic data linking lower cholesterol to reduced dementia risk in a lab setting.
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Genetic study links lower cholesterol to reduced dementia risk

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A large-scale genetic analysis of about 1.09 million people suggests that lifelong, genetically lower cholesterol—specifically non‑HDL cholesterol—is associated with substantially reduced dementia risk. Using Mendelian randomization to emulate the effects of cholesterol‑lowering drug targets such as those for statins (HMGCR) and ezetimibe (NPC1L1), the study found up to an approximately 80% lower risk per 1 mmol/L reduction for some targets. ([research-information.bris.ac.uk](https://research-information.bris.ac.uk/en/publications/cholesterollowering-drug-targets-reduce-risk-of-dementia-mendelia?utm_source=openai))

A 25-year Swedish study of nearly 28,000 people, published in Neurology, found that higher daily intake of full-fat cheese and cream was associated with a 13% to 24% lower risk of dementia—particularly in those without genetic predispositions—but not for low-fat dairy or those with genetic risks. The findings challenge low-fat dairy recommendations and emphasize overall healthy diets.

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High meat intake may reduce dementia risk for older people with genetic predisposition to Alzheimer's, per a Karolinska Institutet study. The study tracked over 2,100 individuals aged 60 and older for up to 15 years. Findings apply to carriers of specific apoe gene variants.

A large genetic study has found that sharp rises in blood sugar after meals could significantly heighten the risk of Alzheimer’s disease. Researchers from the University of Liverpool analyzed data from over 350,000 UK Biobank participants, revealing a 69% increased risk linked to postprandial hyperglycemia. The effect appears independent of visible brain damage, pointing to subtler biological mechanisms.

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A long-running analysis of nearly 200,000 U.S. health professionals found that both low-carbohydrate and low-fat eating patterns were associated with lower coronary heart disease risk when they emphasized high-quality foods such as whole grains, plant-based sources, and unsaturated fats. Versions of these diets built around refined carbohydrates and animal-based fats and proteins were associated with higher risk, according to a study published in the Journal of the American College of Cardiology (JACC).

Researchers at the University of California, San Francisco, have discovered a mechanism by which exercise helps protect the brain from age-related damage associated with Alzheimer's disease. Physical activity prompts the liver to release an enzyme that repairs the blood-brain barrier, reducing inflammation and improving memory in older mice. The findings, published in the journal Cell, highlight a body-to-brain pathway that could lead to new therapies.

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A new genomic analysis suggests that Alzheimer's disease may begin with inflammation in organs like the skin, lungs, or gut, potentially decades before brain symptoms appear. Researchers analyzed genetic data from hundreds of thousands of people and found risk genes more active outside the brain. This perspective could reshape prevention and treatment strategies.

 

 

 

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