临床试验
Early University of Calgary trial tests high-dose niacin as add-on treatment for glioblastoma
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Researchers at the University of Calgary are studying whether high doses of vitamin B3 (niacin) can improve outcomes for patients with newly diagnosed glioblastoma when added to standard treatment. An interim analysis of 24 patients found a higher-than-expected six‑month progression‑free survival rate, though investigators stress the results are preliminary and require ongoing safety monitoring.
A new experimental oral medication called elecoglipron improved blood sugar control and promoted weight loss in adults with type 2 diabetes during a phase 2b trial. Results from the SOLSTICE study were presented at the American Diabetes Association's Scientific Sessions and published in The Lancet.
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A new treatment called Daraxonrasib has shown strong results against advanced pancreatic cancer in a recent clinical trial. The drug targets a genetic mutation long considered impossible to treat effectively.
武田制药宣布，其AI辅助的口服银屑病药物zasocitinib在晚期试验中证明安全有效。这种每日一次的药片在清除中重度斑块状银屑病患者皮肤方面，优于安慰剂和现有疗法apremilast。如果获批，它将成为首批利用人工智能发现的药物之一。
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An experimental nasal vaccine has for the first time prevented the colonization of whooping cough bacteria in humans, according to a recently published clinical trial. This breakthrough could curb the disease's spread, particularly in a year of record cases in England. The BPZE1 vaccine, developed by ILiAD Biotechnologies, reduced bacterial presence by over 97% compared to placebo.
A combination of enzalutamide and hormone therapy has reduced the risk of death by more than 40% in men with recurring prostate cancer, according to a major clinical trial. The study, involving over 1,000 patients worldwide, was led by researchers at Cedars-Sinai and presented at a medical congress in Berlin. Experts describe the findings as a game changer for treating aggressive cases.
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The U.S. Food and Drug Administration has finalized a rule requiring drug sponsors to submit diversity action plans for clinical trials. This aims to ensure better representation of underrepresented groups in medical research. The rule takes effect in 2025.
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