Anxiety
Anxiety and insomnia tied to lower levels of key immune cells in young women
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A study of young female university students in Saudi Arabia has found that symptoms of anxiety and insomnia are associated with reduced levels of natural killer cells, key components of the immune system’s early defense. The findings suggest that psychological stressors may be linked to weaker immune responses, though the research shows correlation rather than causation and is limited to a small, specific population.
Researchers report that reduced ATP signaling in the dorsal hippocampus of male mice, driven by changes in the protein connexin 43, can trigger both depression- and anxiety-like behaviors. The study, published in The Journal of Neuroscience, finds that chronic stress lowers extracellular ATP and connexin 43 levels, that experimentally reducing the protein induces similar behaviors even without stress, and that restoring it in stressed animals improves behavioral signs of distress.
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Researchers at the University of Utah have found that anxiety in mice is regulated by two groups of microglia, immune cells that act as accelerators and brakes. This discovery challenges the traditional focus on neurons for mental health issues. The findings, published in Molecular Psychiatry, suggest potential new approaches to treating anxiety disorders.