Study associates toxic people with accelerated biological aging

A study funded by the U.S. National Institute on Aging concludes that interacting with problematic people accelerates biological aging. Each additional such person increases biological age by about nine months and speeds up the aging rate by 1.5%.

The study surveyed more than 2,000 people on the prevalence of problematic people in their lives. It then measured their biological age and aging rate using DNA patterns in saliva samples. Findings show that interacting with individuals who cause problems or complications is associated with faster biological aging. Each additional “molestia” in a person's life adds approximately nine months to their biological age. Those with more problematic people aged faster; for each additional one, their aging rate accelerated by 1.5% and increased their biological age by nine months. Biological age measures the organism's real aging, unlike chronological age, which counts time since birth. It has long been known that positive relationships prevent cognitive decline and delay biological aging. Researchers emphasize the importance of minimizing exposure to people who generate high stress and conflicts.

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Illustration of a woman with depression symptoms overlaid with microscopic view of aging monocytes in blood, linking to study on women with and without HIV.
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Study links monocyte “biological aging” in blood to emotional depression symptoms in women with and without HIV

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A study of 440 participants from the Women’s Interagency HIV Study found that accelerated epigenetic aging in monocytes—an immune cell type—tracked more closely with emotional and cognitive depression symptoms such as hopelessness and loss of pleasure than with physical symptoms like fatigue. The work, published in The Journals of Gerontology: Series A, adds evidence that cell-type-specific aging measures could contribute to future biological tools to complement symptom-based depression screening, though researchers say more validation is needed before clinical use.

New research from New York University indicates that anxiety about growing older, particularly concerns over health decline, correlates with accelerated cellular aging in women. The study, involving 726 participants, used epigenetic clocks to measure biological aging rates. Fears related to appearance or fertility showed no similar connection.

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Researchers at Edith Cowan University have proposed that positive travel experiences could help slow some signs of aging. By applying the theory of entropy to tourism, they argue it supports the body's balance and resilience. The findings appear in a 2024 study published in the Journal of Travel Research.

A study involving 73 people with mild cognitive impairment or early dementia found that tailored treatment plans targeting nutritional deficiencies, infections and other factors led to significant cognitive improvements after nine months. Participants in the intervention group saw their overall cognitive scores rise by 13.7 points, while the control group declined by 4.5 points. The approach combines medical interventions with lifestyle changes like diet, exercise and cognitive training.

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Researchers at UCLA have identified a protein that slows muscle repair in aging but enhances cell survival in mice. Blocking the protein improved healing speed in older mice, though it reduced long-term stem cell resilience. The findings suggest aging involves survival strategies rather than mere decline.

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