Alzheimer
Study links sugar metabolism shifts to a temporary survival program in injured neurons
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University of Michigan researchers using fruit flies report that changes in sugar metabolism can influence whether injured neurons and their axons deteriorate or persist. The work, published in *Molecular Metabolism*, describes a context-dependent response involving the proteins DLK and SARM1 that can briefly slow axon degeneration after injury, a finding the team says could inform future strategies for neurodegenerative disease research.
A new brain imaging study has found that recalling facts and personal experiences activates nearly identical neural networks, challenging long-held views on memory systems. Researchers from the University of Nottingham and University of Cambridge used fMRI scans on 40 participants to compare these memory types. The results, published in Nature Human Behaviour, suggest a rethink in how memory is studied and could inform treatments for Alzheimer's and dementia.
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A large study of nearly 2 million older adults has found that cerebral amyloid angiopathy, a condition where amyloid proteins build up in brain blood vessels, sharply increases the risk of dementia. Within five years of diagnosis, people with this disorder were four times more likely to develop dementia than those without it, even absent a history of stroke. The findings, drawn from Medicare records, underscore the need for early cognitive screening in affected individuals.
As the population ages, more people are affected by memory diseases like Alzheimer's. However, research in the field is progressing slowly, and only about half of those affected receive the available treatment.
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Gli scienziati europei hanno sviluppato un metodo preliminare per identificare l'Alzheimer utilizzando una goccia di sangue essiccato da un dito, raggiungendo l'86% di accuratezza nel rilevare la patologia amiloide. Lo studio, validato su 337 pazienti di diversi paesi, è pubblicato su Nature Medicine e mira a semplificare la diagnosi precoce di questa malattia che colpisce oltre 50 milioni di persone in tutto il mondo.
Uno studio svedese suggerisce che consumare più formaggio ad alto contenuto di grassi potrebbe ridurre il rischio di demenza del 13%, sulla base di dati di quasi 30.000 persone seguite per 25 anni. Tuttavia, gli esperti avvertono che si tratta di un'analisi osservazionale senza prova di causalità. I critici evidenziano potenziali confonditori e l'importanza di fattori come la pressione sanguigna e il controllo del peso.
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Alzheimer's trials are shifting to a multi-target approach inspired by cancer research, even after failures with Novo Nordisk's semaglutide. Only two drugs, Eli Lilly's Kisunla and Eisai and Biogen's Leqembi, are widely approved to slow progression. This evolution treats the brain-wasting disease as a complex system, seeking new ways to halt it amid its global impact.
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