阿尔茨海默病

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Microscopic view of injured fruit fly neuron axon, one side degenerating while the other survives via sugar metabolism shift involving DLK and SARM1 proteins, illustrating University of Michigan study.
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Study links sugar metabolism shifts to a temporary survival program in injured neurons

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University of Michigan researchers using fruit flies report that changes in sugar metabolism can influence whether injured neurons and their axons deteriorate or persist. The work, published in *Molecular Metabolism*, describes a context-dependent response involving the proteins DLK and SARM1 that can briefly slow axon degeneration after injury, a finding the team says could inform future strategies for neurodegenerative disease research.

A new brain imaging study has found that recalling facts and personal experiences activates nearly identical neural networks, challenging long-held views on memory systems. Researchers from the University of Nottingham and University of Cambridge used fMRI scans on 40 participants to compare these memory types. The results, published in Nature Human Behaviour, suggest a rethink in how memory is studied and could inform treatments for Alzheimer's and dementia.

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A large study of nearly 2 million older adults has found that cerebral amyloid angiopathy, a condition where amyloid proteins build up in brain blood vessels, sharply increases the risk of dementia. Within five years of diagnosis, people with this disorder were four times more likely to develop dementia than those without it, even absent a history of stroke. The findings, drawn from Medicare records, underscore the need for early cognitive screening in affected individuals.

As the population ages, more people are affected by memory diseases like Alzheimer's. However, research in the field is progressing slowly, and only about half of those affected receive the available treatment.

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European scientists have developed a preliminary method to identify Alzheimer's using a drop of dried blood from a finger, achieving 86% accuracy in detecting amyloid pathology. The study, validated in 337 patients from several countries, is published in Nature Medicine and aims to simplify early diagnosis of this disease affecting over 50 million people worldwide.

A Swedish study suggests that consuming more high-fat cheese could lower dementia risk by 13%, based on data from nearly 30,000 people followed for 25 years. However, experts caution that it is an observational analysis without proof of causality. Critics highlight potential confounders and the importance of factors like blood pressure and weight control.

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阿尔茨海默病试验正转向受癌症研究启发的多靶点方法,即便Novo Nordisk的司美格鲁肽试验失败。只有两种药物——Eli Lilly的Kisunla和Eisai与Biogen的Leqembi——被广泛批准用于减缓疾病进展。这种演变将这种脑部退化疾病视为复杂系统,在其全球影响下寻求新的遏止途径。

 

 

 

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