Research
Decades after a small breast cancer vaccine trial, researchers link lasting immune memory to CD27
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More than 20 years after a small Duke-led clinical trial tested an experimental breast cancer vaccine, Duke Health says all participating women are still alive—an outcome researchers describe as unusual for metastatic disease. Follow-up analyses found long-lived immune cells marked by CD27, and mouse experiments suggest that stimulating CD27 can boost vaccine-driven tumor control.
A randomized trial shows that administering cancer immunotherapy before 3pm can nearly double survival time for patients with non-small cell lung cancer. Researchers found significant benefits from aligning treatment with circadian rhythms during the initial cycles. This marks the strongest evidence yet for chronotherapy in oncology.
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Scientists at the Icahn School of Medicine at Mount Sinai report an experimental CAR T-cell strategy that targets tumor-associated macrophages—the immune cells many tumors use as a protective shield—rather than attacking cancer cells directly. In preclinical mouse models of metastatic ovarian and lung cancer, the approach reshaped the tumor microenvironment and extended survival, with some animals showing complete tumor clearance, according to a study published online January 22 in Cancer Cell.
University of Michigan researchers using fruit flies report that changes in sugar metabolism can influence whether injured neurons and their axons deteriorate or persist. The work, published in *Molecular Metabolism*, describes a context-dependent response involving the proteins DLK and SARM1 that can briefly slow axon degeneration after injury, a finding the team says could inform future strategies for neurodegenerative disease research.
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Scientists at Case Western Reserve University have discovered that asthma may be driven by 'pseudo leukotrienes' formed through free-radical reactions, rather than the traditionally blamed leukotrienes produced by enzymes. These molecules appear at higher levels in asthma patients, correlating with symptom severity. The finding suggests potential new treatments targeting the root cause of inflammation.
A new research paper argues that AI agents are mathematically destined to fail, challenging the hype from big tech companies. While the industry remains optimistic, the study suggests full automation by generative AI may never happen. Published in early 2026, it casts doubt on promises for transformative AI in daily life.
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Japan's education ministry has certified the Institute of Science Tokyo as the second university eligible for aid from a ¥10 trillion government fund. Formed in 2024 by merging the Tokyo Institute of Technology and Tokyo Medical and Dental University, it expects over ¥10 billion in subsidies in its first year. The certification supports a plan to enhance cooperation between medical and engineering researchers.
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