Overactive brain hinders balance recovery in older adults and Parkinson's patients

Researchers at Emory University have discovered that excessive brain and muscle activity during minor balance disruptions contributes to poorer balance recovery in older adults, including those with Parkinson's disease. The study, published in eNeuro, reveals that trying harder to balance may actually increase fall risk. Opposing muscles stiffening simultaneously further impairs stability.

Lena Ting of Emory University and colleagues investigated how aging and Parkinson's disease influence balance responses. In prior experiments with young adults, sudden destabilization—like pulling a rug from under their feet—triggered rapid brainstem and muscle reactions, followed by stronger brain-involved responses for severe challenges. The new study focused on older adults with and without Parkinson's, using similar perturbations. They observed heightened brain responses and muscle activity even for minor disruptions. Ting stated, 'Balance recovery takes more energy and engagement from the brain in these populations. We found that, when people require more brain activity to balance, they have less robust ability to recover their balance.' A notable pattern emerged: activating one muscle for stabilization often caused the opposing muscle to co-contract, creating stiffness that reduced movement efficiency and correlated with worse balance performance. The findings suggest this overactivity, rather than underactivity, underlies many balance problems. Ting added, 'We may be able to determine whether someone has increased brain activity simply by assessing muscle activity after pulling a rug out from under you.' The team, including Scott E. Boebinger, Aiden M. Payne, Jifei Xiao, Giovanni Martino, Michael R. Borich, and J. Lucas McKay, published their work in eNeuro (DOI: 10.1523/ENEURO.0423-25.2026). They propose refining the method to identify at-risk individuals early, enabling targeted training to prevent falls.

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Realistic brain illustration highlighting the SCAN network linked to Parkinson’s disease, with targeted therapy stimulation and improving patient hand tremor.
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Study links Parkinson’s disease to a newly described ‘somato-cognitive’ brain network, suggesting a potential target for therapy

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Researchers analyzing brain-imaging and treatment data from hundreds of people report that Parkinson’s disease is associated with abnormal connectivity involving the somato-cognitive action network (SCAN), a motor-cortex network described in 2023. In a small trial, stimulation aimed at this network produced a higher response rate than stimulation of nearby motor areas, raising the possibility of more targeted noninvasive treatments.

Researchers at the University of California, Riverside, have identified how inflammation in multiple sclerosis disrupts mitochondrial function in the brain, leading to the loss of key neurons that control balance and coordination. Published in the Proceedings of the National Academy of Sciences, the findings highlight a potential pathway for new treatments to preserve mobility in the 2.3 million people affected by the disease worldwide. The study examined human brain tissue and a mouse model to trace these energy failures over time.

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Researchers at McGill University have challenged the conventional understanding of dopamine's function in movement, suggesting it acts more like engine oil than a gas pedal. This discovery, published in Nature Neuroscience, could simplify treatments for Parkinson's disease by focusing on maintaining steady dopamine levels. The findings stem from experiments showing that dopamine enables movement without directly controlling its speed or force.

A randomized clinical trial suggests that a year of guideline-level aerobic exercise was associated with small but measurable reductions in an MRI-based estimate of “brain age,” leaving participants’ brains looking close to one year younger than those of a usual-care control group.

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A 47-year longitudinal study from Sweden reveals that physical fitness and strength begin to decline around age 35, regardless of prior exercise habits. However, the research highlights that starting physical activity later in life can still boost capacity by 5 to 10 percent. Conducted at Karolinska Institutet, the findings underscore the benefits of exercise at any age.

Depression diagnosed for the first time in older adults was more common in the years leading up to a diagnosis of Parkinson’s disease or Lewy body dementia and remained elevated for years afterward, according to a large Danish registry study. The authors said the pattern—stronger than in several other chronic illnesses—supports the possibility that depression can be an early feature of these neurodegenerative conditions rather than only an emotional response to disability.

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People with Parkinson's disease experience reduced enjoyment from pleasant smells like lemon, according to a new study. This difference in smell perception could help diagnose the condition earlier and more simply. Researchers found that brain processing of scents varies in those affected, distinguishing them from others with smell loss.

 

 

 

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