Microbiome
Study links microbial glycogen in the gut to inflammation in C9orf72-associated ALS and frontotemporal dementia
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Researchers at Case Western Reserve University report that some gut bacteria can make unusually inflammatory forms of glycogen and that this microbial glycogen can trigger immune activity linked to brain inflammation in models of disease tied to the C9orf72 mutation. In patient stool samples, the team found these glycogen forms more often in ALS and C9orf72-related frontotemporal dementia than in healthy controls, and enzymatically breaking down glycogen in the gut improved outcomes in mice.
Researchers reported at Digestive Disease Week (DDW) 2026 that older mice given fecal microbiota transplants made from their own preserved, younger-age stool samples showed less liver inflammation and injury—and none developed liver cancer in the experiment.
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Both caffeinated and decaffeinated coffee can boost mood and mental performance by influencing gut microbes. Researchers found that polyphenols in coffee drive many of these benefits. The findings come from a controlled trial involving 62 healthy adults.
A small clinical trial shows that faecal microbiota transplants can improve outcomes for kidney cancer patients on immunotherapy drugs. Participants receiving transplants experienced longer cancer stability and greater tumor shrinkage compared to those given placebos. The approach targets the gut microbiome to boost immune responses against tumors.
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Researchers have discovered a unique oral microbiome signature in people with obesity, potentially offering early detection and prevention strategies. The finding, based on saliva samples from Emirati adults, highlights differences in bacteria and metabolic pathways associated with metabolic dysfunction. However, scientists caution that the relationship's causality remains unclear.
A study suggests that owning a dog can change the human microbiome in ways that promote empathetic and social behaviors. Researchers found that adolescents with dogs exhibit less social withdrawal and aggression, linked to specific bacteria. Experiments in mice confirmed these microbes enhance prosocial traits.
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A study from the Institute for Systems Biology shows that defecating one or two times a day correlates with better health markers. Extremes like constipation or frequent diarrhea link to underlying biological issues. Researchers examined data from 1,425 adults to reach these findings.
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