Experimental mRNA vaccine shows protection against multiple ebola viruses

An experimental mRNA vaccine has demonstrated effectiveness against three strains of Ebola virus in rodent tests. The vaccine targets Zaire, Sudan and Bundibugyo viruses. Researchers developed it amid an ongoing outbreak of Bundibugyo virus in Africa.

Yanfeng Yao and colleagues at the Wuhan Institute of Virology created the vaccine by combining mRNA sequences for glycoproteins from each virus along with a shared nucleoprotein inside a lipid nanoparticle. In tests, immunised mice gained complete protection against Zaire and Sudan viruses and strong protection against Bundibugyo. Hamsters also received full protection from Sudan virus exposure.

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Photorealistic lab scene depicting DoriVac DNA origami vaccine triggering strong immune responses in mouse and organ chip models, as an advance over mRNA vaccines.
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DNA origami “DoriVac” shows strong immune activation in early tests, offering a potential complement to mRNA vaccines

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Researchers at Harvard’s Wyss Institute and Dana-Farber Cancer Institute report that a DNA origami-based vaccine platform called DoriVac generated robust immune responses in mice and in a human lymph node “Organ Chip” model. The team says the approach could be easier to store and manufacture than lipid nanoparticle–delivered mRNA vaccines, though the work remains preclinical. The results were published in Nature Biomedical Engineering.

Moderna confirmed ongoing work on an mRNA vaccine for hantavirus following a deadly outbreak on a Dutch cruise ship. The effort, in partnership with Korea University, began in 2023 and shows promise but remains years from completion.

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The World Health Organization has declared a public health emergency over an outbreak of the Bundibugyo strain of Ebola virus in the Democratic Republic of the Congo and Uganda. The move comes as researchers urge faster development of vaccines for lesser-known Ebola strains.

TBE cases in Sweden have tripled over ten years despite rising vaccinations. Åke Lundkvist, professor of virology at Uppsala University, suspects the virus may have changed, reducing vaccine effectiveness. Researchers are now analyzing 12,000 ticks to investigate.

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Egypt's Ministry of Health aims to produce 140 million human vaccine doses annually by 2030 under its Vaccine City project. Health Minister Khaled Abdel Ghaffar reviewed the project's progress, emphasizing efforts for self-sufficiency and exports to regional and international markets.

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