Experimentellt mRNA-vaccin visar skydd mot flera ebolavirus

Svenska

Ett experimentellt mRNA-vaccin har uppvisat effektivitet mot tre stammar av ebolavirus i tester på gnagare. Vaccinet riktar sig mot Zaire-, Sudan- och Bundibugyo-virus. Forskare utvecklade vaccinet under ett pågående utbrott av Bundibugyo-virus i Afrika.

Yanfeng Yao och kollegor vid Wuhan Institute of Virology skapade vaccinet genom att kombinera mRNA-sekvenser för glykoproteiner från varje virus tillsammans med ett gemensamt nukleoprotein inuti en lipidnanopartikel. I tester uppnådde vaccinerade möss ett fullständigt skydd mot Zaire- och Sudan-virus samt ett starkt skydd mot Bundibugyo. Hamstrar erhöll även fullt skydd mot exponering för Sudan-virus.

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