Experimental mRNA vaccine shows protection against multiple ebola viruses

An experimental mRNA vaccine has demonstrated effectiveness against three strains of Ebola virus in rodent tests. The vaccine targets Zaire, Sudan and Bundibugyo viruses. Researchers developed it amid an ongoing outbreak of Bundibugyo virus in Africa.

Yanfeng Yao and colleagues at the Wuhan Institute of Virology created the vaccine by combining mRNA sequences for glycoproteins from each virus along with a shared nucleoprotein inside a lipid nanoparticle. In tests, immunised mice gained complete protection against Zaire and Sudan viruses and strong protection against Bundibugyo. Hamsters also received full protection from Sudan virus exposure.

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A volunteer receiving a needle-free vaccine in a lab with AI-designed virus models in the background.
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AI-designed “pan-sarbecovirus” vaccine candidate reports early safety and immune-response signals in first human trial

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A needle-free, DNA-based vaccine candidate designed using machine-learning methods has completed a first-in-human Phase 1 study in the UK, with researchers reporting it was well tolerated and induced immune responses against multiple viruses in the sarbecovirus group, which includes SARS-CoV, SARS-CoV-2 and related bat coronaviruses.

Researchers have used genetically modified phages to harness pre-existing vaccine immunity and destroy cancer cells in mice. The approach eradicated tumors in 44 percent of treated animals with no recurrence after a year.

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Moderna confirmed ongoing work on an mRNA vaccine for hantavirus following a deadly outbreak on a Dutch cruise ship. The effort, in partnership with Korea University, began in 2023 and shows promise but remains years from completion.

A genetically engineered virus has stopped pancreatic tumors from growing in three patients in an early US clinical trial. The results come from a safety study led by researchers at the University of Minnesota.

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Scientists at Scripps Research have developed a nanodisc platform that mimics viral membranes, uncovering hidden interactions in HIV and Ebola proteins that traditional methods miss. The technology allows for more accurate study of antibody responses, potentially accelerating vaccine development. The findings appear in Nature Communications.

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