Experimental mRNA vaccine shows protection against multiple ebola viruses

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An experimental mRNA vaccine has demonstrated effectiveness against three strains of Ebola virus in rodent tests. The vaccine targets Zaire, Sudan and Bundibugyo viruses. Researchers developed it amid an ongoing outbreak of Bundibugyo virus in Africa.

Yanfeng Yao and colleagues at the Wuhan Institute of Virology created the vaccine by combining mRNA sequences for glycoproteins from each virus along with a shared nucleoprotein inside a lipid nanoparticle. In tests, immunised mice gained complete protection against Zaire and Sudan viruses and strong protection against Bundibugyo. Hamsters also received full protection from Sudan virus exposure.

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Photorealistic lab scene depicting DoriVac DNA origami vaccine triggering strong immune responses in mouse and organ chip models, as an advance over mRNA vaccines.
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DNA origami “DoriVac” shows strong immune activation in early tests, offering a potential complement to mRNA vaccines

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Researchers at Harvard’s Wyss Institute and Dana-Farber Cancer Institute report that a DNA origami-based vaccine platform called DoriVac generated robust immune responses in mice and in a human lymph node “Organ Chip” model. The team says the approach could be easier to store and manufacture than lipid nanoparticle–delivered mRNA vaccines, though the work remains preclinical. The results were published in Nature Biomedical Engineering.

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